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KMID : 1134820070360030305
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 3 p.305 ~ p.310
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Effect of KH-305 on the Nitric Oxide Synthase Activity and Erectile Dysfunction in Young Rats
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Lee Eun-Jeong
Kim Hee-Seok
Kim Byoung-Chul
Hwang Sung-Wan
Hwang Sung-Yeoun
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Abstract
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This study was designed to investigate the effects of KH-305 on erectile dysfunction in young rats, via nitric oxide (NO)-cGMP pathways. After oral administration of the KH-305 mixture (50, 100, 200, 300 ㎎/㎏) to young rats for 10 days, NOS and SOD protein expressions in penile tissue and testosterone in plasma were measured. cGMP degradation was also investigated using bovine vascular smooth muscle cells pretreated with an NO donor, S-nitroso-N-Acetylpenicillamine (SNAP). The penile expression levels of nNOS and eNOS-dependent NOS activities as well as SOD preventing oxidative stress by overproduction of NO were increasedsignificantly. Also, the concentration of testosterone in the plasma was increased. In vitro, cGMP concen-trations were decreased dose dependently in the KH-305. These results suggest that KH-305 may be useful in erectile dysfunction.
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KEYWORD
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erectile dysfunction, NOS, cGMP, testosterone
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